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Blood ; 18 : — Although TP53 , NOTCH1 , and SF3B1 mutations may impair prognosis of patients with chronic lymphocytic leukemia CLL receiving frontline therapy, the impact of these mutations or any other, alone or in combination, remains unclear at relapse. We performed clustering according to both number and combinations of recurrent gene mutations. This multiple-hit profile was associated with a median progression-free survival of 12 months compared with Sign In or Create an Account. Sign In. Content Menu.
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Using whole exome sequencing, the authors performed comprehensive genomic characterization of a 6-person Turkish family with 3 cases of brain AVM without HHT. The authors performed a whole exome capture and Illumina sequencing on blood samples from 2 siblings with AVM. LysGlu was identified in 2 patients via whole exome sequencing.
Blood ; 18 : — Although TP53 , NOTCH1 , and SF3B1 mutations may impair prognosis of patients with chronic lymphocytic leukemia CLL receiving frontline therapy, the impact of these mutations or any other, alone or in combination, remains unclear at relapse. We performed clustering according to both number and combinations of recurrent gene mutations. This multiple-hit profile was associated with a median progression-free survival of 12 months compared with Patient characteristics are shown in supplemental Table 1. Somatic gene mutational status was determined by targeted NGS. According to Illumina RTA v.
